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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Nat Rev Cardiol. 2018 Oct;15(10):631–647. doi: 10.1038/s41569-018-0046-4

Figure 2. Epicardial signals in heart repair and regeneration.

Figure 2.

(A) Organ-wide activation of zebrafish epicardial cells one day after resection of the ventricular apex. Activation (induction of embryonic epicardial markers such as raldh2, wt1, tbx18 and fn) is restricted to the injury site by 7 days after injury. Green color represents the re-expression of embryonic genes. (B) Proposed epicardium-myocardium signals in zebrafish heart regeneration and mammalian heart repair.