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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Nat Rev Cardiol. 2018 Oct;15(10):631–647. doi: 10.1038/s41569-018-0046-4

Figure 4. An epicardium-derived strategy for heart repair.

Figure 4.

Skin fibroblasts from the MI patient could be reprogrammed into induced pluripotent stem cells (iPS cells) and further differentiated into induced epicardial cells (iEpicardial cells) by defined factors (see section 6.3). iEpicardial cells could be activated through treatment with small molecules or pro-regenerative factors (sections 4 and 6.1), and engineered with ECM components (section 4.2) into a patch (section 6.2) to be applied to the MI.