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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Environ Int. 2018 Jul 5;119:250–263. doi: 10.1016/j.envint.2018.06.024

Fig. 1. Illustration of study plan and characters of study population.

Fig. 1

A. The study was conducted in Hetao Basin, Inner Mongolia, China (Historical drinking water arsenic concentration may be higher than 500 μg/L). F1: Grandparents exposed to arsenic at adulthood; F2: Parents exposed to arsenic in utero and early childhood; F3: Grandchildren with germ cell arsenic exposure. B. Significantly reduced global DNA methylation in patients compared to grandparents in the control and arsenic exposed groups; and C. Horvath’s DNAme age of all samples based on genome-wide DNA methylation data. The chronological ages of volunteers are strongly correlated with predicted Horvath’s predictor based on DNAme profiles (r2 = 0.92).