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In vivo pharmacokinetic profiles of bexarotene (BEX) and its prodrugs following intravenous administration in rats. BEX or prodrugs 2 and 25 were administered at doses equivalent to 2.5 mg/kg of BEX (mean ± SD, n = 3 each). Pharmacokinetic profile of BEX following intravenous administration of BEX has been previously reported by our group [33] and is shown here for comparison.
