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. 2018 Sep 18;8:13986. doi: 10.1038/s41598-018-32236-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differential proteome analysis of from primary tumors, liver metastases and ovarian metastases. (A) Total number of human, murine and homologous proteins identified by proteome analysis of IR-laser ablated tissue homogenates from primary tumors, liver metastases and ovarian metastases (pie charts on the left); Number of proteins found to be regulated at the different sites (bar chart on the right, discriminating between proteins with human or homologous peptide sequence). (B) Gene names of the top 10 proteins up- or down-regulated at both sites. (C) Validation of the decreased expression of junctional plakoglobin (JUP) in liver metastases compared to primary tumor as indicated in (B). Moreover, JUP was found to be particularly weakly expressed in lung micro-metastases, while large, macroscopically visible ovarian metastases showed strong JUP expression similar to primary xenograft tumors. (D) Absolute numbers and gene names of proteins regulated in both ovarian and liver metastases (concordant overlap).