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. 2018 Sep 18;8:13986. doi: 10.1038/s41598-018-32236-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differential proteome analysis of cultured cells. (A) Total number of human, murine and homologous proteins identified by proteome analysis of lysates of cultured cells of primary tumor (PT), liver metastasis (Met-L) and ovarian metastasis (Met-O) sublines. (B) Number of proteins found to be regulated at the different sites. The embedded tables in (C) display the gene names of proteins found to be up- or down-regulated at both sites (top 10 in the case of Met-O cells, all proteins in the case of Met-L cells). The table in (D) shows gene names of proteins that were regulated in both the IR-laser ablated tissue homogenates of in vivo specimens and cell lysates of in vitro sublines.