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. 2018 Sep 18;8:13974. doi: 10.1038/s41598-018-32413-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Evaluation of taxa trend in the gut microbiota of HT and CpT samples. Asterisks indicate statistically significant differences between each case-control for all five datasets (P-value <0.05). The heatmap shows the taxonomic trend of each 16S rRNA gene-based metagenomic dataset. Names of identified bacterial taxa are listed on the left, while names of sample groups used are listed at the top. Healthy Marginal Tissue (HMT); Colonic Mucosa with Polyps(CMP); ColoRectal Cancer (CRC); all Healthy Tissue (HT) and CRC-polyps Tissue (CpT). The green color represents high abundance in healthy cases, red color represents high abundance in disease cases and black color represents the absence of the bacterial taxa. Columns show the studies analyzed and rows indicate the bacterial taxonomy at genus level.