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. 2018 Sep 18;8:13979. doi: 10.1038/s41598-018-32334-0

Figure 6.

Figure 6

15d-PGJ2-loaded NC decrease MSU-induced Nlrp3, Asc, Pro-caspase-1, and Pro-Il-1β mRNA expression, and NF-κB activation in a PPAR-γ-sensitive manner. Fifteen hours after MSU, knee joint was collected for RT-qPCR assay to ascertain the mRNA expression of ASC (A), Pro-caspase-1 (B), NLRP3 (C), Pro-Il-1β (D), and ELISA to ascertain NF-κB activation (E). Schematic summary of data (F). Results are mean ± SEM, n = 6 mice per group in each experiment, two independent experiments (*p < 0.05 vs. control group; #p < 0.05 vs. vehicle mg/kg group, **p < 0.05 vs 15d-PGJ2-loaded NC. One-way ANOVA and post-test of Tukey).