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. 2018 Sep 18;8:14012. doi: 10.1038/s41598-018-32356-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional analysis of the omics data performed by IPA software. For both the SILAC and RNA-Seq data, candidates that were imported into the IPA software occurred in all replicates and showed significant up- or down-regulation in AHCY silenced cells compared to the controls. (A) The upper section is a rough overview to display common changes in the datasets and the most prominent molecular and cellular functions based on the significance range (p-value). (B) The lower section is a graphical representation of the functional categories selected based on the categories that are of the highest relevance to cancer signalling, control of the cell cycle and DNA damage. The p-value is calculated using the right-tailed Fisher’s exact test and was set to less than 0.05 for the upper panel to indicate a statistically significant, non-random association but lowered to 0.00 for graphical representation to evaluate pathways probably associated with the data based on the portion/percentage of the up- and down-regulated or not present molecules involved in the pathway and represented on the bar in red, green or white colour. For each bar, the number of identified up- or down-regulated molecules is shown.