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. 2018 Sep 18;8:14017. doi: 10.1038/s41598-018-32336-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Phagosomes accumulate following treatment with PI3K/Akt/mTor inhibitors. (a) Accumulation of phagosomes, which are packets of shed ROS that can be detected with Rhodopsin immunolabeling, following disrupted RPE phagocytosis or digestion. (b) Signaling pathways targeted by compounds that resulted in phagosome accumulation. (c) Compounds that target the PI3K/Akt/mTor pathway lead to phagosome accumulation as compared to the DMSO control. Merged images show GFP-expressing rods in green, HA-mCherry^TM stripe in red, and Rhodopsin immunolabeling in blue. Scale bar is 10 μm.