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. 2018 Feb 15;25(9):1581–1597. doi: 10.1038/s41418-018-0063-1

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© ADMC Associazione Differenziamento e Morte Cellulare 2018

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Fig. 4 — miRNA expression profile and mapping of Ago2–RNA interactions by PAR-CLIP during C2C12 differentiation. a Small RNA sequencing revealed that myomiRs were remarkably upregulated remarkable during C2C12 cell differentiation. myomiRs are indicated in red color. C2C12 myoblasts cultured in growth medium (D0) and in C2C12 myotubes maintained in differentiation medium (DM) for 6 or 10 days. b The relative expression of partial miRNAs that had >2-folds changes in small RNA sequencing were analyzed by qRT-PCR. c, d Functional enrichment of miRNA target genes found by Ago2-PAR-CLIP before and after C2C12 cell differentiation. c Top 20 enriched Gene ontology (GO) biological process terms. d Top 20 enriched KEGG pathways. FDR false discovery rate; Percentage, number of genes involved in one particular terms divided by total genes