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. 2018 Sep 18;9:3805. doi: 10.1038/s41467-018-05777-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Screening progression cascade. The Global Health Chemical Diversity Library (GHCDL) was screened in parallel against Plasmodium falciparum asexual stage and male and female gametocyte. Actives were reconfirmed and cytotoxic compounds removed. Asexual hits were further filtered based upon potency and 26 compounds selected for further profiling based upon potency and commercial availability. Five compounds with different transmission-blocking properties were further investigated for activity phenotype against male gametogenesis and their physiochemical properties (DMPK) investigated. Activity of three molecules was confirmed by standard membrane-feeding assay (SMFA)