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. 2018 Sep 18;9:3805. doi: 10.1038/s41467-018-05777-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Chemical structure of GHCDL compounds selected for further study. Five compounds showing a range of transmission-blocking activity at the profiling stage were selected for detailed study. DDD01027599 (found to actually be BPCA—see Supplementary Fig. 1-2) and DDD01245291 are active against gametocytes and asexuals; DDD01255968 and DDD01249504 are active specifically against male gametocytes; and DDD01035881 specifically targets male gamete formation