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. 2018 Sep 12;9:2092. doi: 10.3389/fimmu.2018.02092

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Copyright © 2018 Chen, Zhang, Liu, Lu, Liang, Qiu, Han and Dai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Esculetin reduces the PASI score and ameliorates the skin lesion of IMQ-induced psoriasis-like mice. (A) The representatives of photos of dorsal skin in IMQ-induced psoriasis-like mice 7 days after IMQ-treatment without or with esculetin. (B) The PASI scores of the skin lesion in IMQ-induced psoriasis-like mice on days 3, 5, and 7 after related treatment. (C) The daily mouse weight during the treatment. (D–G) Immunohistochemical images of CD3 or CD8 staining (magnification: 100X) of dorsal skin in control or psoriatic mice 7 days after the treatment. Data are presented as the mean ± SD (n = 4–6 mice/group, *p < 0.05 and **p < 0.01 vs. vehicle group). One representative of three separate experiments is shown. (ES-L: low-dose of esculetin and ES-H: high-dose of esculetin).