Table 1.

Effect of PVA MBs in mice at different times post-injection: complete blood count (CBC). To be considered that values with an asterisk are within the reference range although significantly differ from the control (p < 0.05).

CBC	Reference values	Control Mean ± SD	10 min Mean ± SD	100 min Mean ± SD	1 day Mean ± SD	7 days Mean ± SD	30 days Mean ± SD
WBC (103/mm3)	5.0–12.0	8.5 ± 4.0	10.7 ± 3.6	6.7 ± 1.1	8.3 ± 2.4	11.2 ± 0.3∗	9.8 ± 4.6
LYMF (%)	65.0–80.0	64.9 ± 8.8	74.0 ± 12.2	56.8 ± 10.2	69.6 ± 4.8	76.7 ± 2.4	73.9 ± 11.7
MID (%)	0.0–10.0	16.8 ± 10.1	9.4 ± 2.8	23.9 ± 8.1	5.2 ± 0.1	6.2 ± 0.8	7.0 ± 2.4
GRAN (%)	10.0–30.0	18.3 ± 3.1	16.5 ± 15.0	19.3 ± 4.5	25.2 ± 4.9	17.1 ± 2.1	19.2 ± 14.1
LYMF (103/mm3)	4.0–10.0	5.6 ± 1.6	7.7 ± 1.8	4.0 ± 1.0	5.7 ± 1.3	8.6 ± 0.2∗	7.6 ± 4.6
MID (103/mm3)	0.0–2.0	1.3 ± 0.7	1.0 ± 0.3	1.5 ± 0.4	0.4 ± 0.2	0.7 ± 0.1	0.8 ± 0.6
GRAN (103/mm3)	0.5–6.0	1.6 ± 0.4	2.1 ± 2.3	1.3 ± 0.5	2.2 ± 1.1	1.9 ± 0.3	1.4 ± 0.7
RBC (106/mm3)	9.0–13.0	9.81 ± 0.54	9.49 ± 0.24	9.79 ± 0.86	9.32 ± 0.71	9.19 ± 0.33	9.1 ± 0.6
HGB (g/dL)	10.0–19.0	16.5 ± 0.7	16.8 ± 0.7	16.1 ± 0.5	16.3 ± 0.4	16.0 ± 1.0	14.5 ± 1.6
HCT (%)	40.0–55.0	44.3 ± 1.7	45.9 ± 2.0	44.6 ± 0.5	43.2 ± 0.6	42.3 ± 2.4	42.4 ± 2.2
MCV (μm3)	39.0–49.0	45.2 ± 1.2	48.4 ± 3.4	45.8 ± 3.7	46.6 ± 4.3	46.0 ± 2.6	46.5 ± 2.5
MCH (pg)	13.0–20.0	16.8 ± 0.3	17.7 ± 1.1	16.5 ± 1.3	17.6 ± 1.8	17.5 ± 0.9	15.9 ± 1.2
MCHC (g/dL)	30.0–39.0	37.2 ± 0.9	36.6 ± 0.7	36.0 ± 0.8	37.7 ± 0.6	37.9 ± 0.8	34.1 ± 2.0
RDW (%)	0.0–99.9	16.2 ± 1.9	17.8 ± 0.2	17.9 ± 3.1	16.3 ± 0.9	16.4 ± 0.6	16.8 ± 1.2
PLT (103/mm3)	600–1400	1077 ± 135	1059 ± 180.6	1423 ± 52∗	1230 ± 194	1132 ± 139	1072.8 ± 638.4
MPV (μm3)	4.0–7.0	5.2 ± 0.2	5.3 ± 0.2	5.2 ± 0.3	5.1 ± 0.1	5.2 ± 0.3	5.9 ± 0.8