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. 2018 Sep 17;4(9):e00796. doi: 10.1016/j.heliyon.2018.e00796

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© 2018 Published by Elsevier Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Akt-regulated microRNAs differentially regulate PCa pathways in the early and advanced stages. (A) Principle component analysis (PCA) mapping of TRAMP/Akt1^+/+ and TRAMP/Akt1^–/– profiling. TRAMP/Akt1^+/+ group (indicated by red color) was clustered distinctly from TRAMP/Akt1^–/– group (indicated by blue color). (B) Principle component analysis (PCA) mapping of 31 weeks old, 5 weeks treated TRAMP + DMSO and TRAMP+ Triciribine prostate tissue profiling. TRAMP + DMSO group (indicated by blue color) was clustered distinctly from TRAMP+ Triciribine group (indicated by red color). (C) Table showing pathways affected by the microRNA expression in TRAMP/Akt1^–/– compared to TRAMP/Akt1^+/+ mouse prostates as determined by the KEGG pathway analysis. (D) Table showing pathways affected by the microRNA expression in TRAMP + Triciribine compared to TRAMP + DMSO mouse prostates as determined by the KEGG pathway analysis.