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. 2018 Sep 17;4(9):e00796. doi: 10.1016/j.heliyon.2018.e00796

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© 2018 Published by Elsevier Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — MicroRNA expression changes in TRAMP/Akt1^–/– mouse prostates compared to TRAMP/Akt1^+/+ show the integral role of Akt1 in cell survival and proliferation. (A) Selected miRNAs differentially regulated in TRAMP/Akt1^–/– mouse prostates compared to TRAMP/Akt1^+/+. (B) Signaling network analysis using Ingenuity Pathway Analysis software involving microRNAs identified from the study indicating the integral role of Akt1-regulated microRNAs in cell survival, proliferation and growth in the early stage PCa.