Figure 7.

Validation of the miR-17-3p Radiosensitization Effect In Vivo

(A) Male nude mice were implanted with PC-3 cells and allowed tumor growing to reach 500 mm³; the expression of miR-17-3p was induced by drinking Dox-containing water, and the tumors were treated with 5× 3-Gy IR as indicated. The tumor growths in the indicated groups were routinely measured. (B) Tumor volume changes in the different groups were calculated. (C) The levels of MnSOD, Gpx2, and TrxR2 in tumor tissues were determined by western blots with β-actin normalization. (D) The activities of the three antioxidant enzymes in the tumor tissues were measured. Values are presented as the mean ± SD (n ≥ 6). Statistical significances between two groups are as described in Figure 1.