Table 3. Factors associated with PAD and CAD.

	Model 1		Model 2		Model 3
	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
PAD
Age (per 10 yrs)	2.33 (1.44–3.77)	< 0.01	2.27 (1.39–3.70)	< 0.01	2.33 (1.40–3.87)	< 0.01
Gender (male)	---	NS	---	NS	---	NS
Hypertension	---	NS	---	NS	---	NS
Hyperlipidemia	---	NS	---	NS	---	NS
Statin	2.27 (1.10–4.66)	0.03	---	NS	---	NS
HDL-C (per 1 mg/dL)	0.96 (0.93–0.99)	0.02	---	NS	---	NS
Smoking	---	NS	---	NS	---	NS
Diabetes mellitus	---	NS	---	NS	---	NS
Anti-platelet drugs	---	NS	---	NS	---	NS
FGF-21(< 15.6 pg/mL)	2.10 (1.01–4.40)	0.04	2.15 (1.02–4.49)	0.04	---	NS
CAD			5.23 (1.96–13.9)	< 0.01
3-vessel disease					4.86 (2.34–10.1)	< 0.01
CAD
Age (per 10 yrs)	1.50 (1.20–1.88)	< 0.01	1.43 (1.14–1.79)	< 0.01
Gender (male)	2.22 (1.30–3.79)	< 0.01	2.21 (1.29–3.80)	< 0.01
Hypertension	---	NS	---	NS
Hyperlipidemia	2.53 (1.57–4.09)	< 0.01	2.48 (1.53–4.01)	< 0.01
Statin	---	NS	---	NS
HDL-C (per 1 mg/dL)	0.97 (0.95–0.99)	< 0.01	0.97 (0.95–0.99)	< 0.01
Smoking	---	NS	---	NS
Diabetes mellitus	2.14 (1.23–3.69)	< 0.01	2.13 (1.23–3.69)	< 0.01
Anti-platelet drugs	2.58 (1.64–4.05)	< 0.01	2.51 (1.59–3.96)	< 0.01
FGF-21(< 15.6 pg/mL)	---	NS	---	NS
PAD			3.37 (1.20–9.45)	0.02
3-vessel disease
Age (per 10 yrs)	1.93 (1.39–2.70)	< 0.01	1.82 (1.29–2.56)	< 0.01
Gender (male)	2.54 (1.21–5.31)	0.01	2.23 (1.07–4.64)	0.03
Hypertension	---	NS	---	NS
Hyperlipidemia	---	NS	---	NS
Statin	1.94 (1.09–3.45)	0.02	---	NS
HDL-C (per 1 mg/dL)	0.97 (0.95–0.99)	0.02	0.97 (0.95–0.99)	0.02
Smoking	---	NS	---	NS
Diabetes mellitus	---	NS	---	NS
Anti-platelet drugs	---	NS	---	NS
FGF-21(< 15.6 pg/mL)	---	NS	---	NS
PAD			4.14 (1.96–8.74)	< 0.01

OR indicates odds ratio; 95%CI, 95% confidence interval.