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Requirement of PERK, IRE1, and Nrf2 for PBMC survival after multiple (5) cycles of I-R. (a) LDH leakage, (b) apoptosis. Data are expressed as mean ± SD; *p < 0.01 vs cycle 1. ¶p < 0.01 vs multiple I-R; §p < 0.05 vs multiple I-R; GSKc39 = GSK compound 39, trigo = trigonelline.
