Table 2.
Genotype and allelic frequencies of the TSPAN2 SNPs in patients and controls.
| SNP | Genotypes and alleles | Migraine n% | Control n% | Crude | Crude | Adjusted | Adjusted | |
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P-value | aOR (95% CI) | P-value | |||||
| TSPAN2 rs12134493 | Genotype | CC CA |
359 (84.5%) 64 (15%) |
364 (85.7%) 60 (14.1%) |
1 1.082 (0.739–1.583) |
0.687 | 1 1.128 (0.766–1.660) |
0.543 |
| AA | 2 (0.5%) | 1 (0.2%) | 2.028 (0.183–22.463) | 0.564 | 1.882 (0.164–21.645) | 0.612 | ||
| Dominant model | AA | 2 (0.5%) | 1 (0.2%) | 1 | 1 | |||
| CA+CC | 423 (99.5%) | 424 (99.8%) | 0.499 (0.045–5.522) | 0.571 | 0.540 (0.047–6.205) | 0.621 | ||
| Recessive model | CC | 359 (84.5%) | 364 (85.7%) | 1 | 1 | |||
| CA + AA | 66 (15.5%) | 61 (14.3%) | 1.097 (0.752–1.600) | 0.631 | 1.141 (0.778–1.673) | 0.498 | ||
| Allele | C | 782 (92%) | 788 (92.7%) | 1 | 1 | |||
| A | 68 (8%) | 62 (7.3%) | 1.105 (0.773–1.581) | 0.584 | 1.143 (0.795–1.641) | 0.471 | ||
| TSPAN2 rs2078371 | Genotype | TT TC |
379 (89.2%) 46 (10.8%) |
343 (80.7%) 81 (19.1%) |
1 0.514 (0.348–0.759) |
0.001 | 1 0.529 (0.356–0.784) |
0.002 |
| CC | 0 | 1 (0.2%) | n.a. | n.a. | n.a. | n.a. | ||
| Dominant model | CC | 0 | 1 (0.2%) | 1 | 1 | |||
| TC+TT | 425 (100%) | 424 (99.8%) | n.a. | n.a. | n.a. | n.a. | ||
| Recessive model | TT | 379 (89.2%) | 343 (80.7%) | 1 | 1 | |||
| TC+CC | 46 (10.8%) | 82 (19.3%) | 0.508 (0.344–0.749) | 0.001 | 0.523 (0.353–0.774) | 0.001 | ||
| Allele | T | 804 (94.6%) | 767 (90.2%) | 1 | 1 | |||
| C | 46 (5.4%) | 83 (9.8%) | 0.529 (0.364–0.768) | 0.001 | 0.523 (0.353–0.774) | 0.002 |
CI, confidence interval; OR, odds ratio; n, number; n.a., not applicable; a, Adjusted for age and sex. Significant P-values are in bold.