Table 3.
Genotype and allelic frequencies of the TSPAN2 SNPs in patients with different migraine subtypes.
| SNP | Genotypes and alleles | Control n% | Migraine |
OR (95% CI) MA vs. Control |
P-value MA vs. Control |
OR (95% CI) MO vs. Control |
P-value MO vs. Control |
||
|---|---|---|---|---|---|---|---|---|---|
| Without aura n% | With aura n% | ||||||||
| TSPAN2 rs12134493 | Genotype | CC CA |
364 (85.7%) 60 (14.1%) |
299 (84.5%) 53 (15%) |
60 (84.5%) 11 (15.5%) |
1 1.112 (0.553–2.236) |
0.765 | 1 1.075 (0.721–1.604) |
0.722 |
| AA | 1 (0.2%) | 2 (0.5%) | 0 | n.a. | n.a. | 2.435 (0.220–26.982) | 0.468 | ||
| Dominant model | AA | 1 (0.2%) | 2 (0.5%) | 0 | 1 | 1 | |||
| CA+CC | 424 (99.8%) | 352 (99.5%) | 71 (100%) | n.a. | n.a. | 0.415 (0.037–4.597) | 0.474 | ||
| Recessive model | CC | 364 (85.7%) | 299 (84.5%) | 60 (84.5%) | 1 | 1 | |||
| CA+AA | 61 (14.3%) | 55 (15.5%) | 11 (15.5%) | 1.094 (0.545–2.198) | 0.801 | 1.098 (0.739–1.630) | 0.644 | ||
| Allele | C | 788 (92.7%) | 651 (91.9%) | 131 (92.3%) | 1 | 1 | |||
| A | 62 (7.3%) | 57 (8.1%) | 11 (7.7%) | 1.067 (0.548–2.080) | 0.848 | 0.899 (0.618–1.307) | 0.576 | ||
| TSPAN2 | Genotype | TT | 343 (80.7%) | 320 (90.4%) | 59 (83.1%) | 1 | 1 | ||
| rs2078371 | TC | 81 (19.1%) | 34 (9.6%) | 12 (16.9%) | 0.861 (0.442–1.677) | 0.66 | 0.450 (0.293–0.691) | 0.000259 | |
| CC | 1 (0.2%) | 0 | 0 | n.a. | n.a. | n.a. | n.a. | ||
| Dominant model | CC | 1 (0.2%) | 0 | 0 | 1 | 1 | |||
| TC + TT | 424 (99.8%) | 354 (100%) | 72 (100%) | n.a. | n.a. | n.a. | n.a. | ||
| Recessive model | TT | 343 (80.7%) | 320 (90.4%) | 59 (83.1%) | 1 | 1 | |||
| TC+CC | 82 (19.3%) | 34 (9.6%) | 12 (16.9%) | 0.851 (0.437–1.656) | 0.634 | 0.444 (0.290–0.682) | 0.000203 | ||
| Allele | T | 767 (90.2%) | 674 (95.2%) | 130 (91.5%) | 1 | 1 | |||
| C | 83 (9.8%) | 34 (4.8%) | 12 (8.5%) | 0.853 (0.453–1.607) | 0.623 | 0.466 (0.309–0.704) | 0.000259 | ||
CI, confidence interval; OR, odds ratio; n, number; vs, versus; n.a., not applicable; Significant P-values are in bold.