Table 4.
Genotype and allelic frequencies of the TSPAN2 SNPs in patients with different gender subtypes.
| SNP | Genotypes and alleles | Control n% | Migraine | OR (95% CI) | P-value | OR (95% CI) | P-value | ||
|---|---|---|---|---|---|---|---|---|---|
| Female vs. control | Female vs. control | Male vs. control | Male vs. control | ||||||
| Male n% | Female n% | ||||||||
| TSPAN2 | Genotype | CC | 364 (85.7%) | 57 (79.2%) | 302 (85.5%) | 1 | 1 | ||
| rs12134493 | CA | 60 (14.1%) | 15 (20.8%) | 49 (13.9%) | 0.984 (0.655–1.479) | 0.939 | 1.596 (0.849–3.000) | 0.146 | |
| AA | 1 (0.2%) | 0 | 2 (0.6%) | 2.411 (0.218–26.714) | 0.473 | n.a | n.a | ||
| Dominant model | AA | 1 (0.2%) | 0 | 2 (0.6%) | 1 | 1 | |||
| CA + CC | 424 (99.8%) | 72 (100%) | 351 (99.4%) | 0.414 (0.037–4.584) | 0.472 | n.a | n.a | ||
| Recessive model | CC | 364 (85.7%) | 57 (79.2%) | 302 (85.5%) | 1 | 1 | |||
| CA + AA | 61 (14.3%) | 15 (20.8%) | 51 (14.5%) | 1.008 (0.674–1.506) | 0.97 | 1.570 (0.836–2.949) | 0.16 | ||
| Allele | C | 788 (92.7%) | 129 (89.6%) | 653 (92.5%) | 1 | 1 | |||
| A | 62 (7.3%) | 15 (10.4%) | 53 (7.5%) | 1.032 (0.705–1.510) | 0.873 | 1.478 (0.816–2.676) | 0.197 | ||
| TSPAN2 | Genotype | TT | 343 (80.7%) | 63 (87.5%) | 316 (89.5%) | 1 | 1 | ||
| rs2078371 | TC | 81 (19.1%) | 9 (12.5%) | 37 (10.5%) | 0.496 (0.326–0.753) | 0.001 | 0.605 (0.289–1.267) | 0.183 | |
| CC | 1 (0.2%) | 0 | 0 | n.a | n.a | n.a | n.a | ||
| Dominant model | CC | 1 (0.2%) | 0 | 0 | 1 | 1 | |||
| TC + TT | 424 (99.8%) | 72 (100%) | 353 (100%) | n.a | n.a | n.a | n.a | ||
| Recessive model | TT | 343 (80.7%) | 63 (87.5%) | 316 (89.5%) | 1 | 1 | |||
| TC + CC | 82 (19.3%) | 9 (12.5%) | 37 (10.5%) | 0.490 (0.323–0.743) | 0.001 | 0.598 (0.285–1.251) | 0.172 | ||
| Allele | T | 767 (90.2%) | 135 (93.8%) | 669 (94.8%) | 1 | 1 | |||
| C | 83 (9.8%) | 9 (6.2%) | 37 (5.2%) | 0.511 (0.342–0.763) | 0.001 | 0.616 (0.302–1.25) | 0.182 | ||
CI, confidence interval; OR, odds ratio; n, number; n.a., not applicable. Significant P-values are in bold.