Table 6.

Genotype-phenotype association of the two SNPs and migraine features in MA group.

Migraine with aura	rs12134493		rs2078371
Migraine trait	OR (95% CI)	P-value	OR (95% CI)	P-value
Unilateral migraine	0.314 (0.049–2.008)	0.221	0.841 (0.196–3.611)	0.841
Pulsating headache	0.086 (0.003–2.925)	0.173	n.a.	n.a.
Severe headache	1.607 (0.117–22.091)	0.723	3.132 (0.498–19.683)	0.223
Aggravation by physical activity	0.447 (0.054–3.714)	0.456	0.650 (0.105–4.030)	0.644
Nausea/vomiting	41.058 (2.272–749.923)	0.012	8.780 (0.543–144.291)	0.128
Phonophobia	0.137 (0.011–1.767)	0.128	0.721 (0.089–5.842)	0.76
Photophobia	3.381 (0.259–44.112)	0.353	1.450 (0.152–13.870)	0.747
Family history	5.051 (0.537–47.519)	0.157	2.645 (0.391–17.888)	0.319
Average age of onset ≤ 27 years	1.043 (0.111–9.825)	0.971	0.411 (0.054–3.134)	0.391
Menstruation-associateda	0.112 (0.006–2.010)	0.137	0.274 (0.025–3.003)	0.289

CI, confidence interval; OR, odds ratio. Significant P-values are in bold.

Age and sex-adjusted logistic regression models comparing the minor allele.

^aAll female migraine patients.