Figure 1.

Effect of Tan IIA on DOX-induced pathomorphological changes in mice. Mice were treated with Tan IIA or normal saline from days 1–7 and DOX was administered at day 5. Mice were then sacrificed at day 8 and heart tissues were stained with hematoxylin and eosin. (A) Control; (B) DOX (18 mg/kg); (C) DOX (18 mg/kg) + Tan IIA (15 mg/kg); (D) DOX (18 mg/kg) + Tan IIA (30 mg/kg); (E) Tan IIA (30 mg/kg). Regions of myocardial fiber fragmentation and gap enlargement are indicated by black arrows. The magnification of images is ×100. Tan IIA, tanshinone IIA; DOX, doxorubicin.