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. 2018 Aug 17;16(4):3333–3344. doi: 10.3892/etm.2018.6614

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Copyright: © Guo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Effect of Tan IIA on Nrf2 mRNA and its downstream genes expression in DOX-treated mice heart. The mRNA expression of (A) Nrf2, and its downstream genes, including (B) HO-1, (C) NQO1, (D) GCLC, (E) MRP2 and (F) P-gp were determined by reverse transcription-quantitative polymerase chain reaction. Data are presented as the mean ± standard error of the mean (n=6). *P<0.05, **P<0.01 and ***P<0.001 vs. the control; ^#P<0.05, ^##P<0.01 and ^###P<0.001 vs. DOX. Tan IIA, tanshinone IIA; Nrf2, nuclear factor (erythroid-derived 2)-like 2; DOX, doxorubicin; HO-1, heme oxygenase-1; NQO1, NAD(P)H dehydrogenase (quinone) 1; GCLC, glutamate-cysteine ligase catalytic subunit; MRP2, multidrug resistance-associated protein 2; P-gp, P-glycoprotein.