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. 2018 Aug 17;16(4):3333–3344. doi: 10.3892/etm.2018.6614

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Copyright: © Guo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Effect of Tan IIA on relative mRNA expression of Nrf2 and its downstream genes in H9c2 cells. The mRNA expression of (A) Nrf2, and its downstream genes expression including (B) HO-1, (C) NQO1, (D) GCLC, (E) MRP2 and (F) P-gP were determined by reverse transcription-quantitative polymerase chain reaction. Data are presented as mean ± standard error of the mean (n=3). *P<0.05 and ***P<0.001 vs. the control; ^#P<0.05, ^##P<0.01 and ^###P<0.001 vs. DOX. Tan IIA, tanshinone IIA; Nrf2, nuclear factor (erythroid-derived 2)-like 2; HO-1, heme oxygenase-1; NQO1, NAD(P)H dehydrogenase (quinone) 1; GCLC, glutamate-cysteine ligase catalytic subunit; MRP2, multidrug resistance-associated protein 2; P-gp, P-glycoprotein; DOX, doxorubicin; tBHQ, tertbutyl hydroquinone.