Table 2.

Multivariate analysis of overall survival

Variables	HR	95% Confidence Interval	P value
Age
<45 (reference)	1	‐
45‐64	0.86	0.78‐0.96	0.0067
>=65	0.94	0.84‐1.06	0.3432
Sex
Male (reference)	1	‐
Female	0.83	0.71‐0.97	0.0191
Tumor location
U/3 (reference)	1	‐
M/3	0.94	0.87‐1.02	0.1116
L/3	0.87	0.80‐0.96	0.0048
Tumor length
<5 cm	1	‐
≧5 cm	1.25	1.16‐1.35	<0.0001
Grade
G1	1	‐
G2	0.86	0.72‐1.03	0.1103
G3/G4	0.93	0.77‐1.12	0.4376
Clinical T classification
T1 (reference)	1	‐
T2	1.45	1.24‐1.69	<0.0001
T3	1.91	1.64‐2.23	<0.0001
T4	2.79	2.36‐3.30	<0.0001
Clinical N classification
N0 (reference)	1	‐
N1	1.18	1.07‐1.30	0.0012
N2	1.27	1.14‐1.43	<0.0001
N3	1.41	1.24‐1.60	<0.0001
Clinical M classification
M0 (reference)	1	‐
M1	1.68	1.54‐1.83	<0.0001
Treatment
CCRT	1	‐
Only surgery	0.62	0.54‐0.70	<0.0001
CCRT + surgery	0.48	0.43‐0.53	<0.0001
Surgery + adjuvant	0.72	0.64‐0.81	<0.0001
Others	1.75	1.58‐1.94	<0.0001

HR, hazard ratio.