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. 2018 Jul 17;7(9):4598–4609. doi: 10.1002/cam4.1682

Figure 6.

Figure 6

MiR‐335‐5p reduced the DDP‐resistance and inhibited the growth of A2780/DDP cells in vivo. A, The tumor size was significantly smaller in mice treated with DDP when miR‐335‐5p was upregulated or BCL2L2 was downregulated; B, Tumor volume was lower in A2780/DDP + BCL2L2 siRNA + DDP group than in A2780/DDP + miR‐335‐5p mimics + BCL2L2 siRNA + DDP group, **P < 0.01; C, Tumor weight was remarkably reduced in A2780/DDP + miR‐335‐5p mimics + DDP group and A2780/DDP + BCL2L2 siRNA + DDP group than in A2780/DDP + miR‐335‐5p mimics + BCL2L2 siRNA + DDP group, **P < 0.01; D, The BCL2L2 protein was low expressed when DDP‐treated A2780/DDP was transfected with miR‐335‐5p mimics or BCL2L2 siRNA, **P < 0.01 compared with A2780/DDP group. DDP: cisplatin