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. 2018 Aug 9;7(9):4610–4618. doi: 10.1002/cam4.1691

Figure 1.

Figure 1

Cryptotanshinone (CT) suppresses cell proliferation by inhibiting cell glycolysis. A, In Hey and A2780cell lines, exposure to bufalin resulted in significant decrease in cell viability compared with control in a dose‐dependent manner. B, Analysis of cell function regulated by gene‐chip assay. C‐D, The results of real‐time PCR and Western blot exhibited that mRNA level and protein level of GLUT1, LDHA, and HK2 were down‐regulated by treatment of CT (*P < 0.05, **P < 0.01). E, The treatment of CT caused glucose uptake decreased in Hey and A2780 cells when compared to controls (*P < 0.05, **P < 0.01). F, Lactate production was reduced by the treatment of CT in Hey and A2780 cells when compared to controls (*P < 0.05, **P < 0.01). G, The results of Colony formation assay exhibited that CT's inhibitory effect on colony formation ability was obviously weakened by the treatment of CT when compared to controls (*P < 0.05, **P < 0.01)