Table I.
Top 10 upregulated pathways in active fibrovascular membranes.
| Term | P-value | n | Gene symbols |
|---|---|---|---|
| ECM-receptor interaction | 6.88E-20 | 29 | CD36, COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL5A1, COL5A2, COL6A1, COL6A2, COL6A3, FN1, HMMR, HSPG2, TNC, ITGA1, ITGA2, ITGA4, ITGA5, ITGB1, LAMA4, LAMB1, LAMC1, SPP1, THBS1, THBS2, ITGA11, COL5A3, AGRN |
| Focal adhesion | 2.86E-15 | 37 | ACTN1, BIRC2, CCND1, CAV1, COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL5A1, COL5A2, COL6A1, COL6A2, COL6A3, DOCK1, FN1, TNC, ITGA1, ITGA2, ITGA4, ITGA5, ITGB1, LAMA4, LAMB1, LAMC1, PDGFB, PDGFRB, PGF, SPP1, THBS1, THBS2, VEGFC, ZYX, ITGA11, COL5A3, PARVG, MYLK2, |
| Protein digestion and absorption | 1.23E-07 | 16 | COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL5A1, COL5A2, COL6A1, COL6A2, COL6A3, COL12A1, COL15A1, SLC1A5, COL5A3, COL18A1, SLC36A1 |
| Amoebiasis | 1.13E-06 | 17 | ACTN1, COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL5A1, COL5A2, FN1, IL1B, LAMA4, LAMB1, LAMC1, PLCB2 TGFB3 TNF, COL5A3 |
| Leishmaniasis | 3.00E-05 | 12 | CYBA, FCGR1A, HLA-DMB, HLA-DOA, HLA-DQA1, IL1B, ITGA4, ITGB1, STAT1, TGFB3, TNF, MARCKSL1 |
| Small cell lung cancer | 3.61E-05 | 13 | BIRC2, CCND1, CDK6, CDKN2B, COL4A1, COL4A2, E2F2, FN1, ITGA2, ITGB1, LAMA4, LAMB1, LAMC1 |
| Rheumatoid arthritis | 7.51E-05 | 13 | CD28, HLA-DMB, HLA-DOA, HLA-DQA1, IL1B, PGF, CCL2, CCL3, CCL3L1, TGFB3, TNF, TNFSF13B, CCL3L3 |
| Cytokine-cytokine receptor interaction | 1.95E-04 | 24 | BMPR2, IL1B, IL2RB, INHBB, CXCL10, CXCL9, TNFRSF11B, PDGFB, PDGFRB, CCL2, CCL3 CCL3L1, CCL8, TGFB3, TNF, TNFSF4, TNFRSF4, VEGFC, TNFRSF10D, TNFSF13B, TNFRSF21, TNFRSF12A, CCL4L1, CCL3L3 |
| Pathways in cancer | 7.78E-04 | 26 | BIRC2, BIRC5, CCND1, RUNX1, CDK6, CDKN2B, COL4A1, COL4A2, E2F2, ETS1, FN1, ITGA2, ITGB1, LAMA4, LAMB1, LAMC1, MMP9, PDGFB, PDGFRB, PGF, RALA, STAT1, TGFB3, HSP90B1, VEGFC, LEF1 |
| Leukocyte transendothelial migration | 8.65E-04 | 13 | ACTN1, CDH5, CYBA, CYBB, ITGA4, ITGB1, MMP9, MSN, PECAM1, THY1, CLDN5, CLDN1, ESAM |