Table II.
Top 10 upregulated pathways in inactive fibrovascular membranes.
| Term | P-value | n | Gene symbols |
|---|---|---|---|
| ECM-receptor interaction | 1.52E-13 | 21 | COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL5A1, COL5A2, COL6A1, COL6A3, COL11A1, COMP, TNC, ITGA1, ITGA2, ITGA5, LAMA4, LAMB1, LAMC1, THBS1, THBS2, ITGA11 |
| Rheumatoid arthritis | 6.31E-12 | 20 | CD86, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB4, IL1B, IL6, ITGAL, PGF, CCL2, CCL3, CCL3L1, CCL5, TNF, TNFSF13B, CCL3L3 |
| Cell adhesion molecules (CAMs) | 1.31E-09 | 21 | CD2, CD6, CD8A, CD86, CD58, CDH2, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB4, ITGAL, NRCAM, CLDN11, PECAM1, CLDN5, CLDN1, ICOS |
| Staphylococcus aureus infection | 1.34E-09 | 14 | C3AR1, C5AR1, FCGR1A, CFH, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB4, CFI, ITGAL |
| Graft-vs.-host disease | 3.67E-09 | 12 | CD86, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB4, IL1B, IL6, TNF |
| Focal adhesion | 4.98E-09 | 25 | ACTN1, COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL5A1, COL5A2, COL6A1, COL6A3, COL11A1 COMP, TNC, ITGA1, ITGA2, ITGA5 LAMA4, LAMB1, LAMC1, PGF, RAC2, THBS1, THBS2, ITGA11, PARVG |
| Asthma | 1.89E-08 | 10 | FCER1G, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB4, TNF |
| Intestinal immune network for IgA production | 2.65E-08 | 12 | CD86, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB4, IL6, TNFSF13B, ICOS |
| Amoebiasis | 4.21E-08 | 17 | ACTN1, CD14 COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL5A1, COL5A2, COL11A1, IL1B, IL6, LAMA4, LAMB1, LAMC1, PLCB2, TNF |
| Type I diabetes mellitus | 7.95E-08 | 11 | CD86, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB4, IL1B, TNF |