. 2018 Jul 2;9(30):6446–6450. doi: 10.1039/c8sc02138d

Table 2. Substrate scope ^a .

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^aReaction conditions: 1a–y (0.1 mmol), amides (0.1 mmol), 3g (15 mol%), LiHMDS (12 mol%), 4 Å MS (70 mg) in toluene (2.0 mL); isolated yields.

^bReaction performed at –78 °C.

^cReaction performed with amide 2i. Diastereoisomeric ratio (dr) determined by ¹H NMR and HPLC analysis. Enantiomeric excess (ee) determined by HPLC analysis on a chiral stationary phase.

Table 2. Substrate scope a .

Table 2. Substrate scope ^a .