Figure 1.

Interaction between MDM2 and compounds from sea cucumbers. Docking of (A) a tetra-substituted imidazole, a known MDM2 inhibitor, (B) ds-echinoside A and (C) philinopside E to MDM2. At the top, MDM2 presented in green ribbon structure with ligands presented as red spheres. In the middle, hydrophobicity surface map of the active site of MDM2 with the ligands presented as red cylinders. At the bottom, cylinder representation of the ligands with carbon atoms in grey, nitrogen in blue, chlorine in green, oxygen in red and hydrogen in white, to emphasize ligand orientation. MDM2, mouse double minute 2 homolog.