Fig. 1. (a) Internalization of Ctx and ADCs 8 and 9 in Capan-1 (pancreas carcinoma), A549 and NCI-H1975 (lung carcinoma) human cells, and (b) their effect on acetylation of HDAC-target proteins in NCI-H1975 cells. Insets show specific fluorescence signals within the cells. Each image is representative of at least 5 fields of duplicate wells. Magnification 60×. Data are from one representative experiment out of two.
