Table 1.
Revised original scoring system of the International Autoimmune Hepatitis (AIH) Group*
| Points | Case report | ||
| Sex | Female | 2 | X |
| ALP:AST (or ALT) ratio | >3 | −2 | |
| <1.5 | 2 | X | |
| IgG (or gamma globulin) level above normal | >2 | 3 | |
| 1.5–2 | 2 | ||
| 1–1.5 | 1 | X | |
| <1 | 0 | ||
| ANA, SMA or anti-LKM1 titres | >1:80 | 3 | X |
| 1:80 | 2 | ||
| 1:40 | 1 | ||
| <1:40 | 0 | ||
| AMA | Positive | −4 | |
| Viral markers | Positive | −3 | |
| Negative | 3 | X | |
| Drugs | Yes | −4 | |
| No | 1 | X | |
| Alcohol | <25 g/day | 2 | X |
| >60 g/day | −2 | ||
| HLA | DR3 or DR4 | 1 | |
| Immune disease | Thyroiditis, colitis, others | 2 | X |
| Other markers | Anti-SLA, anti-actin, anti-LC1, pANCA | 2 | X |
| Histological features | Interface hepatitis | 3 | X |
| Plasmacytic | 1 | ||
| Rosettes | 1 | ||
| None of above | −5 | ||
| Biliary changes | −3 | ||
| Other features | −3 | ||
| Treatment response | Complete | 2 | X |
| Relapse | 3 | ||
| Total | 23†‡ |
*Adapted from Manns et al.20
†Pretreatment aggregate score: >15, definite diagnosis; 10–15, probable diagnosis.
‡If assume turmeric is possible drug cause, total score is 18, definite AIH.
ALP, alkaline phosphatase; ALT, alanine transaminase; AST, aspartate aminotransferase; LC1, liver cytosol antibody; LKM1, liver kidney microsomes-1 antibody; SMA, smooth-muscle antibody; SLA, soluble liver antigen antibody.