Figure 3.

Changes from baseline in HRQOL according to the worst grades (grade ≥2 vs grade 0 or 1) of AEs during the first 8 wk. There were 20 patients with grade ≥2 and 113 with grade 0 or 1 mucositis/stomatitis, 27 with grade ≥2 and 106 with grade 0 or 1 decreased appetite, 4 with grade ≥2 and 129 with grade 0 or 1 alopecia, 12 with grade ≥2 and 121 with grade 0 or 1 constipation, 28 with grade ≥2 and 105 with grade 0 or 1 fatigue, and 18 with grade ≥2 and 115 with grade 0 or 1 nausea. *P < .05; **P < .01 (linear mixed‐effects model), bars; mean ± SEM