Table 3.
Univariate and multivariable prognostic analyses were performed using the Cox proportional hazard model
| Variables | Univariate | Multivariable | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P‐valuea | HR | 95% CI | P‐valuea | |
| Early skin reaction | ||||||
| Grade ≥ 2 vs grade 0 or 1 | 0.50 | 0.24‐0.95 | .035 | 0.48 | 0.21‐0.97 | .040 |
| Second‐line chemotherapy | ||||||
| Presence vs absence | 0.50 | 0.74‐2.63 | .036 | 0.46 | 0.22‐0.97 | .042 |
| Age | ||||||
| Age ≥70 vs <70 (y) | 2.07 | 1.16‐3.73 | .014 | 1.97 | 1.03‐3.77 | .042 |
| ECOG PS | ||||||
| PS ≥1 vs PS 0 | 2.55 | 1.35‐4.67 | .005 | 1.59 | 0.71‐3.39 | .253 |
| Gender | ||||||
| Male vs female | 1.34 | 0.71‐2.70 | .373 | 1.39 | 0.68‐3.05 | .375 |
| Chemotherapy backbone | ||||||
| mFOLFOX6 vs FOLFIRI | 1.36 | 0.74‐2.63 | .327 | 1.16 | 0.53‐2.42 | .702 |
| Pre‐emptive skin treatment | ||||||
| Presence vs absence | 1.09 | 0.47‐3.15 | .856 | 1.06 | 0.51‐2.16 | .877 |
| Site of primary tumor | ||||||
| Colon vs rectum | 1.58 | 0.30‐1.21 | .174 | 1.48 | 0.71‐3.35 | .302 |
| Primary tumor | ||||||
| Presence vs absence | 1.47 | 0.80‐2.63 | .206 | 1.14 | 0.60‐2.26 | .720 |
| Number of metastatic lesions | ||||||
| 1 vs ≥2 | 0.84 | 0.44‐1.52 | .561 | 1.06 | 0.51‐2.16 | .877 |
| Metastatic sites | ||||||
| Liver only vs the other | 0.58 | 0.32‐1.04 | .068 | 0.61 | 0.84‐3.24 | .145 |
PS, Performance status.
Cox proportional hazard model.
Bold values show statistical significance (P < .05).