Table 1.
Profile of all cases of primary intracranial leiomyosarcoma among HIV-infected population
| Author | Age/sex | Location | CD4 count (cells/mm3) |
Time from HIV diagnosis (years) | ART | EBV | Treatment | Outcome (months) |
| Litofsky et al32 | 50/M | Occipital | 27 | 6 | NR | EBER-1 (+) | CR | NED 8 mos |
| Bejjani et al39 | 38/M | Lateral sphenoid | NR | 0 | NR | EBV LMP (−) | CR | NED 12 mos |
| Brown et al25 | 34/F | Pontine cistern | 177 | 2 | − | EBER-1 (+) | PR+Rx | AWD 12 mos |
| Blumentha et al5 | 43/M | Cavernous sinus | 23 | 12 | NR | EBER (+) EBV LMP (−) |
Ch, Bx/excision |
AWD 24 mos |
| Ritter et al40 | 5/F | Cavernous sinus | NR | 4 | NR | EBNA 2 (+) | PR | NR |
| Citow et al41 | 31/F | Parasellar | NR | 0.5 | NR | EBV IHC (+) | PR | NR |
| Lerdlum et al27 | NR | NR | 20–160 | NR | NR | NR | Sx+Rx | NR |
| Zevallos-Giampietri et al26 | 29/M | Parasellar | NR | 3 | + | EBER (+) EBV LMP (−) |
PR+Rx | AWD 6 mos |
| Suankratay et al36 | 43/F | Multifocal | 26 | 4 | + | EBER-1 (+) | CR+Rx | DOC 4 mos |
| 49/F | Multifocal | 26 | 4 | + | EBER-1 (+) | PR+Rx | AWD 10 mos | |
| 34/F | Tentorium cerebelli | 7 | 5 | + | EBER-1 (+) | CR+Rx | NED 8 mos | |
| 31/F | Multifocal | 3 | 1 | − | EBER-1 (+) | PR+Rx | AWD 5 mos | |
| 35/M | Multifocal | 20 | 0 | + | EBER-1 (+) | CR+Rx | AWD 4 mos | |
| Gupta et al31 | 17/F | Paracentral | 22 | 14 | − | EBER (+) | Bx+Rx+Ch | AWD 15 mos |
| Sivendran et al8 | 43/M | Frontal | 14 | NR | + | EBER (+) | CR | NED 20 mos |
| Muengtawee pongsa10 | 33/M | Cavernous sinus | NR | 1.5 | NR | NR | PR | NR |
| Francisco et al (2017) | 29/M | Multifocal | 7 | 0 | + | NA | CR+Rx+Ch | AWD 23 mos |
| Francisco et al (2017) | 36/M | Multifocal | 144 | 1 | + | NA | CR+Rx+Ch | AWD 27 mos |
AWD, alive with disease; Bx, biopsy; Ch, chemotherapy; CR, complete resection; DOC, dead of other causes; DOD, dead of disease; EBER, Epstein-Barr Early RNA; EBNA, EBV nuclear antigen; EBV, Epstein-Barr virus; F, female; M, male; mos, months; NA, not applicable; NED, No evidence of disease; NR, not reported; PR, partial resection; Rx, radiotherapy; Sx, unspecified surgery.