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. 2017 Mar 22;56(3):145–149. doi: 10.3960/jslrt.56.145

Figure 1.

Figure 1

TET2 mutation in DLBCL and TET2 protein

A. Sanger sequence of TET2 in case 16. Electropherogram of TET2 exon3 sequences showing the monoallelic mutation c.2057_2058delGAinsAGG (note in red). The DNA and corresponding amino acid sequences of the wild-type and mutant TET2 alleles are also shown.

B. A schematic representation of the TET2 protein. The arrowhead shows the position corresponding to the mutation. This mutation led to premature termination p.R686KfsX7. Truncated-form mutant TET2 lacks the cysteine-rich domain (CD) and double stranded b-helix (DSBH) 2OG-Fe(II)-dependent dioxygenase domain.