Table 1. Clinical features of the patients of BPDCN.
No | Age/ Sex |
Neoplastic cell involvement at the time of diagnosis |
G-band | Treatment | Outcome & neoplastic cell involvement at the end stage |
---|---|---|---|---|---|
1 | 73/ M |
Skin, BM (Minimal involvement) | Skin
sample: 96,XXYY,i(1)(q10),+8,+8,+8,+8,inc(4) |
Hyper CVAD/MA | Dead, 38 months Skin, BM, LN, PB, cerebrum, cerebellum |
2 | 83/ M |
Skin, BM (Leukemic), LN, PB, spleen | BM
sample: 45,X,-Y,add(6)(q21),add(9)(q22?), add(17)(q11.2)[12]/46,XY[4] |
Supportive therapy | Dead, 5 months Skin, BM, LN, PB |
3 | 73/ M |
Skin, BM (Leukemic), LN, PB | BM
sample: 46,XY,add(11)(q13),?der(20)t(11;20)(q13;q11.2)[9]/45-46,XY,add(11)(q13), ?der(20)t(11;20)(q13;q11.2)[cp4]/46,XY |
Hyper CVAD/MA Radiation therapy to the head lesion of skin |
Dead, 15 months Autopsy; Skin, BM, LN, PB, heart, lung, liver, spleen, kidney, pancreas, adrenal gland, thyroid gland, testis, esophagus, urinary bladder, peritoneum |
4 | 37/ M |
Skin, BM (Minimal involvement), PB | BM sample: Normal karyotype |
Hyper CVAD/MA Allo-HSCT |
Alive, 34 months (on follow-up) |
5 | 35/ M |
Skin, BM (Minimal involvement) | BM sample: Normal karyotype |
Hyper CVAD/MA Auto-PBSCT |
Alive, 75 months (The follow-up was ended at this time due to the patient’s opinion) |
6 | 74/ M |
Skin, BM (Leukemic), PB | ND | CHOP | Alive, 4 months (on follow up) |
M, male; BM, bone marrow; LN, lymph node; PB, peripheral blood; CVAD, cyclophosphamide, doxorubicin, vincristine and dexamethasone; MA, methotrexate and cytarabine; Allo-HSCT, allogeneic hematopoietic stem cell transplantation; Auto-PBSCT, autologous peripheral blood stem cell transplantation; CHOP, cyclophosphamide, doxorubicin, vincristine and prednisolone, ND; no data.