Table 2.
Correlations between α‐SMA expression by CAFs and clinicopathological characteristics in patients with ICC
| α‐SMA expression by CAFs, no. (%) | |||
|---|---|---|---|
| Clinicopathological characteristics | Negative | Positive | P‐value |
| Age (years) | 0.829 | ||
| <60 | 11 (19.6) | 45 (80.4) | |
| ≥60 | 9 (18.0) | 41 (82.0) | |
| Gender | 0.174 | ||
| Female | 11 (25) | 33 (75) | |
| Male | 9 (14.5) | 53 (85.5) | |
| HBV infection | 0.969 | ||
| Absent | 12 (18.8) | 52 (81.3) | |
| Present | 8 (19.0) | 34 (81.0) | |
| Primary sclerosing cholangitis | 0.381 | ||
| Absent | 19 (20.0) | 76 (80.0) | |
| Present | 1 (9.1) | 10 (90.9) | |
| Cirrhosis regardless of etiology | 0.675 | ||
| Absent | 16 (19.8) | 65 (80.2) | |
| Present | 4 (16.0) | 21 (84.0) | |
| Preoperative CA19‐9 (U/mL) | 0.511 | ||
| <35 | 5 (15.2) | 28 (84.8) | |
| ≥35 | 15 (20.5) | 58 (79.5) | |
| Tumor size (mm) | 0.024 | ||
| <50 | 13 (28.9) | 32 (71.1) | |
| ≥50 | 7 (11.5) | 54 (88.5) | |
| Tumor number | 0.03 | ||
| Single | 20 (22.5) | 69 (77.5) | |
| Multiple | 0 (0) | 17 (100) | |
| Vascular invasion | 0.47 | ||
| Absent | 16 (20.5) | 62 (79.5) | |
| Present | 4 (14.3) | 24 (85.7) | |
| Lymph node metastasis | 0.012 | ||
| Absent | 16 (27.6) | 42 (72.4) | |
| Present | 4 (8.3) | 44 (91.7) | |
| Histological grade | 0.038 | ||
| Well or moderate | 14 (26.9) | 38 (73.1) | |
| Poor | 6 (11.1) | 48 (88.9) | |
| Perineural invasion | 0.638 | ||
| Absent | 18 (19.6) | 74 (80.4) | |
| Present | 2 (14.3) | 12 (85.7) | |