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. 2018 Sep 10;8(9):e022690. doi: 10.1136/bmjopen-2018-022690

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© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Patients’ enrolment and allocation in accordance to the Consolidated Standards of Reporting Trials (CONSORT) stand is displayed. Of note, two stratifications are implemented in the randomisation procedure: first, for patients who suffered from a previous stroke or systemic thromboembolic (TE) event which must have occurred at least 3 months before enrolment without residual limitations (only value of 0 or 1 on the modified Rankin scale). Second, for patients who were already assigned to an oral anticoagulation whose proportion will be limited to 50% of the entire study cohort. INR, international normalised ratio.