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. 2018 Sep 17;8(9):e023220. doi: 10.1136/bmjopen-2018-023220

Table 2.

HR of hearing impairment according to baseline HbA1c (n=202 975)

HbA1c (%) (mg/dL) P for quadratic
<5.0 (<91) 5.0–5.4 (91–110) 5.5–5.9 (111–125) 6.0-.6.4 (126–139) 6.5–6.9 (140–153) 7.0–7.9 (154–182) ≥8 (≥183)
Low frequency
 Men
  Person-year 54 055 275 953 261 290 44 807 11 798 10 637 11 613
  No cases 84 447 548 122 45 26 39
  Model 1 1.15 (0.91 to 1.45) 1.00 0.98 (0.86 to 1.11) 0.94 (0.77 to 1.15) 1.11 (0.81 to 1.51) 0.73 (0.49 to 1.08) 1.22 (0.88 to 1.70) 0.15
  Model 2 1.11 (0.88 to 1.40) 1.00 1.00 (0.88 to 1.14) 0.98 (0.79 to 1.20) 1.16 (0.84 to 1.60) 0.75 (0.49 to 1.15) 1.26 (0.88 to 1.80) 0.27
 Women
  Person-year 28 447 137 761 143 295 25 083 4136 2760 2576
  No cases 65 415 553 133 18 14 9
  Model 1 1.04 (0.80 to 1.35) 1.00 0.90 (0.79 to 1.03) 0.94 (0.77 to 1.14) 0.71 (0.44 to 1.14) 0.86 (0.51 to 1.48) 0.68 (0.35 to 1.31) 0.79
  Model 2 1.04 (0.80 to 1.35) 1.00 0.91 (0.80 to 1.03) 0.93 (0.76 to 1.14) 0.67 (0.41 to 1.10) 0.77 (0.43 to 1.38) 0.57 (0.28 to 1.19) 0.51
High frequency
 Men
  Person-year 53 617 273 025 257 812 44 093 11 621 10 345 11 424
  No cases 280 1610 1941 416 116 128 130
  Model 1 1.05 (0.92 to 1.19) 1.00 0.98 (0.91 to 1.04) 0.91 (0.82 to 1.02) 0.82 (0.67 to 0.99) 1.05 (0.88 to 1.26) 1.15 (0.96 to 1.38) 0.003
  Model 2 1.03 (0.90 to 1.17) 1.00 0.99 (0.92 to 1.06) 0.93 (0.83 to 1.03) 0.84 (0.69 to 1.02) 1.08 (0.89 to 1.32) 1.18 (0.97 to 1.43) 0.007
 Women
  Person-year 28 520 138 232 143 882 25 246 4124 2753 2555
  No cases 23 169 277 67 18 13 15
  Model 1 1.02 (0.66 to 1.58) 1.00 1.00 (0.83 to 1.22) 0.97 (0.73 to 1.29) 1.43 (0.88 to 2.34) 1.62 (0.92 to 2.86) 2.41 (1.42 to 4.10) 0.03
  Model 2 1.03 (0.66 to 1.60) 1.00 0.97 (0.80 to 1.17) 0.86 (0.64 to 1.16) 1.17 (0.70 to 1.95) 1.24 (0.67 to 2.29) 1.78 (0.95 to 3.34) 0.08

Model 1: Adjusted for age.

Model 2: Adjusted for age, walking time, smoking status, alcohol consumption, self-reported diabetes, BMI, hypertension and hyperlipidaemia.

BMI, body mass index; HbA1c, haemoglobin A1c.