Figure 2.

Automated cascade detector for pathological high frequency oscillations (pathHFO) (A) Schematic of multi‐feature cascade pathHFO detector. Data are preprocessed (filtered, segmented, and demeaned). Artifact rejection removes data segments with high 60 Hz noise and anomalously high amplitudes. (B) Receiver‐operator‐curve (ROC) using “gold standard” pathHFO identified by expert visual review constructed by varying the threshold of event‐to‐background ratio. The ROC for multifeature cascade detector outperforms each single feature detector (inset shows ROC additional features improve performance). The performance of the pathHFO cascade detector shows improved sensitivity and specificity with each additional feature detector. (C) Exemplary pathHFO events. Raw data (top) & band passed filtered data (bottom).