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. 2018 Sep 19;6(18):e13878. doi: 10.14814/phy2.13878

Figure 1.

Figure 1

A selective EP4 antagonist CJ‐42794 attenuated angiotensin II‐induced AAA. (A) Time‐course of angiotensin II infusion and CJ‐42794 treatment. (B) Representative images of the abdominal aorta from control and CJ‐42794‐treated (0.2 mg/kg per day) groups (Control and CJ, respectively). Scale bars, 1 mm. (C) Quantification of maximum external diameter of angiotensin II‐induced AAA in ApoE−/− mice. n = 5 (Control) and 6 (CJ). (D) Representative elastica van Gieson stain images of traverse section of angiotensin II‐induced AAA. Scale bars, 200 μm. (E) Medial elastic fiber degradation was graded using an arbitrary scale from grade 1 to grade 4. n = 5 (Control) and 6 (CJ). (F and G) Quantification of MMP‐2 and MMP‐9 activation in mouse AAA tissues measured using gelatin zymography. n = 5 (Control) and 6 (CJ). The data were obtained from two independent experiments.