Figure 5.

Rates of change in brain volumes from term‐equivalent age to 11 years of age, contrasted between treatment groups. Results are from separate mixed effects models for each brain region, adjusted for sex of the child. The plots show the estimated means and 95% confidence intervals (CI) per group for each time point and the rate of change between time points from the mixed models. The y‐axes show the volumes and the x‐axes show age. Units are cm³ for volumes and years for age. The results are based on the total number of children who had usable MRI data at either term‐equivalent age or 11 years of age; for the intracranial cavity, total brain tissue, cerebrospinal fluid, deep nuclear gray matter and cerebellum, n = 187 (n = 70 with term‐equivalent data plus n = 117 with 11‐year data); for the cortical gray matter, white matter and brainstem, n = 182 (n = 70 with term‐equivalent data plus n = 112 with 11‐year data); for the hippocampus, n = 179 (n = 62 with term‐equivalent data plus n = 117 with 11‐year data).