Table I.

IC₅₀ of MK-1775 against ALL cell lines.

Cell line	Cell type	p53	IC50, nM
Nalm-6	B-ALL	WT	45.9±3.9a
Sup-T1	T-ALL	MUT	347.4±95.0a
Jurkat	T-ALL	MUT	137.4±33.9a
Molt-4	T-ALL	MUT	67.6±31.8a
HS-5	BMSC	WT	1,472.0±304.8

ALL, acute lymphoblastic leukemia; B-ALL, B-cell acute lymphoblastic leukemia; T-ALL, T-cell acute lymphoblastic leukemia; WT, wild type; MUT, mutation. MUT, mutated; WT, wild type; p%£, tumor protein 53; IC₅₀, half-maximal inhibitory concentration.

^aP<0.05 compared with HS-5 cell line.