Table 3.
Comparison of demographics and clinical data among groups defined by body mass index in patients with sepsis
| Characteristics | Underweight (n=33) |
Normal (n=98) |
Overweight (n=36) |
Obese (n=11) |
P values |
| Age (years) | 79.0 (69.0–86.0) | 78.0 (67.0–84.0) | 73.0 (57.0–83.0) | 77.0 (71.0–86.0) | 0.162 |
| Males | 24 (72.7) | 70 (71.4) | 20 (55.6) | 2 (18.2) | 0.002 |
| Comorbidities | |||||
| COPD | 8 (24.2) | 21 (21.4) | 0 | 3 (27.3) | 0.017 |
| Diabetes mellitus | 8 (24.2) | 25 (25.5) | 9 (25.0) | 5 (45.5) | 0.530 |
| Hypertension | 14 (42.4) | 38 (38.8) | 19 (52.8) | 7 (63.6) | 0.265 |
| Cerebrovascular disease | 10 (30.3) | 24 (24.5) | 11 (30.6) | 0 | 0.193 |
| Neoplasm | 7 (21.2) | 14 (14.3) | 8 (22.2) | 1 (9.1) | 0.547 |
| Liver disease | 2 (6.1) | 5 (5.1) | 2 (5.6) | 0 | 0.879 |
| Heart failure | 8 (24.2) | 17 (17.3) | 5 (13.9) | 4 (36.4) | 0.319 |
| Chronic renal failure | 5 (15.2) | 14 (14.3) | 7 (19.4) | 3 (27.3) | 0.669 |
| Smoking (pack years) | 0 (0–20.5) | 0 (0–30.0) | 0 (0–3.0) | 0 (0–30.0) | 0.561 |
| Primary site of infection | |||||
| Lung | 27 (81.8) | 69 (70.4) | 27 (75.0) | 8 (72.7) | 0.637 |
| Abdomen | 2 (6.1) | 9 (9.2) | 3 (8.3) | 1 (9.1) | 0.956 |
| Urinary tract | 1 (3.0) | 9 (9.2) | 2 (5.6) | 1 (9.1) | 0.656 |
| Gastrointestinal tract | 2 (6.1) | 6 (6.1) | 3 (8.3) | 1 (9.1) | 0.955 |
| Other site | 1 (3.0) | 5 (5.1) | 1 (2.8) | 0 | 0.800 |
| Community-acquired infection | 25 (75.8) | 76 (77.6) | 26 (72.2) | 8 (72.7) | 0.925 |
| Hypotension | 19 (57.6) | 34 (34.7) | 9 (25.0) | 1 (9.1) | 0.007 |
| Lactate level (mmol/L) | 2.4 (1.6–7.2) | 2.1 (1.0–4.3) | 1.6 (1.2–3.3) | 1.9 (0.6–2.9) | 0.201 |
| Oliguria | 8 (24.2) | 13 (13.3) | 3 (8.3) | 0 | 0.121 |
| Pao2/Fio2 (mm Hg) | 180.0 (113.5–251.0) | 164.5 (102.3–240.5) | 188.0 (140.5–268.5) | 215.0 (153.0–300.0) | 0.340 |
| Serum creatinine (µmol/L) | 89.0 (57.0–127.0) | 118.5 (72.5–190.5) | 91.0 (60.0–212.5) | 86.0 (56.0–112.0) | 0.136 |
| Total bilirubin (µmol/mL) | 18.0 (10.1–33.1) | 14.4 (10.1–28.4) | 17.2 (12.2–26.3) | 15.2 (11.3–20.0) | 0.819 |
| Platelets (×109/L) | 139.0 (75.0–213.0) | 147.0 (86.0–209.8) | 182.5 (128.3–253.8) | 115.0 (49.0–144.0) | 0.056 |
| INR | 1.3 (1.1–1.6) | 1.2 (1.0–1.5) | 1.2 (1.1–1.3) | 1.1 (1.0–1.2) | 0.269 |
| Glasgow Coma Scale | 13.0 (10.0–15.0) | 15.0 (12.0–15.0) | 15.0 (11.0–15.0) | 13.0 (10.0–15.0) | 0.761 |
| SOFA score | 8.0 (5.0–11.0) | 7.0 (5.0–9.0) | 6.0 (4.0–8.0) | 5.0 (5.0–8.0) | 0.382 |
| APACHE II score | 18.0 (16.0–24.0) | 19.0 (13.0–25.0) | 18.0 (13.0–22.0) | 14.0 (9.0–17.0) | 0.060 |
| Septic shock | 19 (57.6) | 30 (30.6) | 9 (25.0) | 1 (9.1) | 0.004 |
| Non-invasive ventilation | 7 (21.2) | 30 (30.6) | 10 (27.8) | 5 (45.5) | 0.466 |
| Intubated | 19 (57.6) | 43 (43.9) | 13 (36.1) | 4 (36.4) | 0.305 |
| Positive blood culture | 7 (21.2) | 24 (24.5) | 4 (11.1) | 3 (27.3) | 0.383 |
| Length of ICU stay (days) | 10.0 (4.0–25.0) | 13.0 (7.0–25.0) | 11.0 (4.0–19.0) | 9.0 (6.0–13.0) | 0.461 |
| Length of hospital stay (days) | 13.0 (4.0–29.0) | 16.0 (10.0–28.0) | 16.0 (8.0–32.0) | 13.0 (8.0–20.0) | 0.813 |
| In-hospital mortality | 20 (60.6) | 41 (41.8) | 11 (30.6) | 2 (18.2) | 0.027 |
| 90-day mortality | 22 (66.7) | 47 (48.0) | 13 (36.1) | 2 (18.2) | 0.015 |
Data are presented as n (%) or median (IQR).
APACHE, Acute Physiology and Chronic Health Evaluation; COPD, Chronic obstructive pulmonary disease; ICU, intensive care unit; INR, international normalised ratio; SOFA, Sequential Organ Failure Assessment.