Figure 7.

The putative nNOS–NOS1AP disruptor ZLc002 suppresses mechanical and cold allodynia induced by paclitaxel treatment. Paclitaxel (a) lowers mechanical paw withdrawal thresholds consistent with the development of mechanical allodynia and (b) increases cold response time, consistent with the development of cold allodynia. ZLc002 (10 mg/kg i.p.) increases (c) mechanical paw withdrawal thresholds and (d) lowers duration of response to cold in paclitaxel-treated mice. ZLc002 (10 mg/kg i.p.) does not alter responsiveness to (e) mechanical or (f) cold stimulation in control mice receiving the cremophor vehicle in lieu of paclitaxel. Data are mean ± S.E.M. *p < 0.05; **p < 0.01; ***p < 0.001 (two-way repeated measures ANOVA followed by Bonferroni’s post hoc test); ^#paired sample t-test baseline vs. postpaclitaxel predrug response. BL: baseline; PTX: paclitaxel.